ABSTRACT
Objective To observe the clinical efficacy of Jiangshabanxia nano-paste on nausea and vomiting in end-stage patients and its effect on the quality-of-life (QOL) in cancer patients. Methods 120 end-stage patients with nausea and vomiting symptoms above grade III were randomly divided into observation group and control group. They were treated with Jiangshabanxia nano-paste and placebo paste respectively. The paste patch was changed every 24 hours and used continuously for 7 days. The nausea and vomiting symptom score, the quality-of-life measurement score and KPS score of cancer patients in the two groups were observed to evaluate the curative effect. Results After 7 days of treatment, the symptom scores of nausea and vomiting in the observation group decreased significantly, the KPS score of the observation group increased, and the effective rate was higher than that in the control group. The score of QOL measurement showed that after treatment, the score of main symptom areas and other symptom areas (except external dyspnea, diarrhea and economic difficulties) in the observation group decreased, and the score of overall health area increased. After treatment, the score of main symptom areas and other symptom areas (except external dyspnea, diarrhea and economic difficulties) in the observation group was lower than that in the control group, and the scores of overall health area in the observation group were higher than those in the control group. Conclusion Jiangshabanxia nano-paste has a good clinical efficacy nausea and vomiting in end-stage patients, it also can improve the quality of life end-stage cancer patients.
ABSTRACT
Organ transplantation is one of the effective methods for the treatment of end-stage diseases, but the lack of donors has hindered the development of organ transplantation. Extracorporeal membrane oxygenation (ECMO) can improve the hypoxia and hypoperfusion of organs, shorten the warm ischemia time, and maintain the function of donor organs effectively, in case of emergency or donor hemodynamic instability. It helps to make effective use of donor organs and benefit patients who are in urgent need of organ transplants. This article summarized the progress on application of ECMO in donor maintenance and provided suggestions for its application in organ transplantation.
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Objective To evaluate the application of the standard manual labeling on identification of retinopathy of prematurity ( ROP) images in deep learning. Methods According to the International Classification of ROP,different periods of ROP were classified into stage disease and plus disease in this study. From Joint Shantou International Eye Center from August 2009 to July 2018, a total of 1464 labeled fundus retinal photographs were divided randomly by stratified sampling into 3 groups:stage disease group(subgroup 1:173,subgroup 2:117) was used to train for labeling stage disease,whereas plus disease group(subgroup 1:163,subgroup 2:116) was used to train for labeling plus disease,and consistent labels group consisted of 895 consistent labeled images on both disease. Graders consisted of senior experts,3 senior ophthalmologists and 2 interns,and received training for classification and labeling on ROP fundus images. The results were compared among the doctors and doctors with deep learning,and the agreement between non-experts doctors and the reference standards, and deep learning and the reference standards were tested. Results After the first training,the overall agreement rate of the senior ophthalmologist group and the intern group were lower than 90％ for both two disease labeling. After two to three times of training, in image of consistent labels group,overall agreement rates of senior ophthalmologists and intern doctor's were 98. 99％ ( Kappa=0. 979),99. 22％ (Kappa=0. 984) on stage disease,and 97. 43％ (Kappa=0. 914),98. 11％ (Kappa=0. 935) on plus disease,respectively. The agreement on stage disease using deep learning based on human-machine combination was 94. 08％,Kappa value was 0. 880,which achieved good degree. Conclusions Standardized manual labeling can improve the intelligentization of deep learning on identification of ROP images,and be considered as an innovative method of homogenization and standardized training for doctors in ophthalmology.
ABSTRACT
Las dermatosis perforantes (DP), o enfermedades por eliminación transepidérmica, son un grupo de enfermedades heterogéneas caracterizadas por una erupción pápulo nodular con extrusión de material dérmico alterado a través de la epidermis. Primariamente su clasificación se basó en la naturaleza del material eliminado y el tipo de perforación (transepidérmica o transfolicular) y se las denominó dermatosis perforantes clásicas, e incluía al elastoma perforante serpiginoso, la colagenosisperforante reactiva, la foliculitis perforante y la enfermedad de Kyrle. La etiopatogenia de la dermatosis perforante adquirida (DPA)es desconocida, presentando una fuerte asociación con traumatismos leves, insuficiencia renal crónica y diabetes mellitus y, con menor frecuencia, con endocrinopatías, enfermedades infectocontagiosas y neoplasias, entre otras. En cuanto al tratamiento, la DPA es una dermatosis de difícil control, con gran tendencia a la recurrencia y cronicidad. Presentamos un caso de DPA, en un paciente masculino de 35 años de edad asociado a diabetes e insuficiencia renal crónica.
Perforating dermatoses (DP), or diseases by transepidermal elimination, are a group of heterogeneous diseases characterized by a papulo-nodular rash with extrusion of altered dermal material through the epidermis. Classification was based primarily on the nature of the material removed and the type of drilling (transepidermal or transfollicular) calling them classic perforating dermatosis, which included perforating serpiginous elastoma, reactive perforating collagenosis, perforating folliculitis, and Kyrles disease. Pathogenesis of acquired perforating dermatosis (APD) is unknown, presenting a strong association with minor injuries, chronic renal failure and diabetes mellitus and, less frequently, endocrine or infectious diseases and neoplasms, among others. Treatment is difficult, with great tendency to recurrence and chronicity. A 35-year-old male with DPA associated with diabetes and chronic kidney failure is reported.
Subject(s)
Humans , Male , Skin Diseases , Diabetes Mellitus , Kidney , Phototherapy , Skin , Skin DiseasesABSTRACT
La figura y función del coordinador de donación es todavía desconocida en nuestra sociedad médica. Debe de existir un coordinador de donación en cada hospital para poder localizar a los potenciales donadores y aprovechar todos los órganos y tejidos posibles. Estudios de diversos países están a favor de la figura de coordinador para aumentar su índice de trasplantes. Debe tener conocimiento de los criterios y estar presente en todos los pasos de una donación para que culminen en trasplante. Debe ser una persona responsable, con liderazgo, comprometida con su puesto y saber que no hay horarios fijos, pero que tendrá como recompensa el devolverle una mejor calidad de vida a los pacientes.
The figure and function of the transplant coordinator is still unknown in our medical society. Every hospital should have a coordinator so this potential organ donors can be identified and have a good use of these organs an tissues. A number of studies around the world have been made and they all agree in the need of a coordinator to increase their transplant numbers. The coordinator must know the criteria and be a part of every step in the donation process, so it will end in a transplant. The coordinator must be a responsible, compromised, with leadership and aware that there are no established work-hours, but having the reward of giving back a life quality to sick people.
ABSTRACT
El objetivo de este estudio fue evaluar la relación de la cognición hacia la enfermedad y el bienestar espiritual con la calidad de vida en 50 pacientes con cáncer en estado terminal de la ciudad de Medellín, Colombia. El diseño del estudio fue exploratorio descriptivo correlacional transversal. Se utilizaron como instrumentos el inventario de bienestar espiritual SIWB, el cuestionario de cognición hacia la enfermedad ICQ y el cuestionario de calidad de vida MQOL. Los resultados a nivel descriptivo indican que los síntomas físicos más graves e insidiosos son dolor, astenia y adinamia. Respecto a la escala total de bienestar espiritual hubo correlaciones positivas con beneficios percibidos del ICQ y bienestar existencial de calidad de vida y negativas con desesperanza del ICQ y síntomas psicológicos de calidad de vida. En conclusión, la espiritualidad y las cogniciones positivas frente a un proceso de enfermedad en estado terminal son variables mediadoras, amortiguadoras y moduladoras de la calidad de vida a nivel físico, psicológico, emocional, social, espiritual y económico.
The aim of this study was to evaluate the relationship between cognition about illness and spiritual well being,and quality of life in 50 patients with terminal cancer in the city of Medellin, Colombia. The study used an exploratory, descriptive, correlational and cross sectional research design. The instruments used were the Spirituality Index of Well-Being SIWB, the Illness Cognition Questionnaire ICQ and the McGill Quality of Life Questionnaire MQOL. Descriptive results show that the more serious and insidious symptoms are body pain, asthenia and adinamia. Regarding the total level of spiritual well-being, positive correlations were found with perceived benefits in the ICQ and existential well-being of quality of life;and negative correlations with helplessness in the ICQ and psychological symptoms of quality of life. In conclusion, spirituality and positive cognitions regarding aterminal disease process are mediating variables, buffers and modulators of the quality of life on the physical, psychological, emotional, social, spiritual and economic level.
O objetivo deste estudo foi avaliar a relação da cognição hacia a doença e o bem estar espiritual com a qualidade de vida em 50 pacientes com câncer em estado terminal da cidade de Medellín, Colômbia. O desenho do estudo foi exploratório descritivo corelacional transversal. Utilizaram-se como instrumentos o inventário de bem-estar espiritual SIWB, o questionário de cognição hacia a doença ICQ e o questionário de qualidade de vida MQOL. Os resultados a nível descritivo indicam que os sintomas físicos mais graves e insidiosos são dor, astenia e adinamia. Respeito à escala total de bem-estar espiritual houve correlações positivas com benefícios percebidos do ICQ e bem-estar existencial de qualidade de vida e negativas com desesperança do ICQ e sintomas psicológicos de qualidade de vida. Em conclusão, a espiritualidade e as cognições positivas frente a um processo de doença em estado terminal são variáveis mediadoras, amortecedoras e moduladoras de a qualidade de vida a nível físico, psicológico, emocional, social, espiritual e econômico.